Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial.

@article{Keynan2010SafetyAE,
  title={Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial.},
  author={Ory Keynan and Yigal Mirovsky and Samuel Dekel and Varda H. Gilad and Gad M Gilad},
  journal={Pain medicine},
  year={2010},
  volume={11 3},
  pages={356-68}
}
Objective. Agmatine, decarboxylated arginine, was shown in preclinical studies to exert efficacious neuroprotection by interacting with multiple molecular targets. This study was designed to ascertain safety and efficacy of dietary agmatine sulfate in herniated lumbar disc-associated radiculopathy. Study Design. First, an open-label dose escalation study was performed to assess the safety and side-effects of agmatine sulfate. In the follow-up study, participants diagnosed with herniated lumbar… CONTINUE READING

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Regulatory mechanisms underlying agmatine homeostasis in humans.

American journal of physiology. Gastrointestinal and liver physiology • 2008

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