• Corpus ID: 12554886

Safety and Clinical Applications

@inproceedings{Sun2007SafetyAC,
  title={Safety and Clinical Applications},
  author={Jidong Sun},
  year={2007}
}
D-limonene is considered to have fairly low toxicity. It has been tested for carcinogenicity in mice and rats. Although initial results showed d-limonene increased the incidence of renal tubular tumors in male rats, female rats and mice in both genders showed no evidence of any tumor. Subsequent studies have determined how these tumors occur and established that d-limonene does not pose a mutagenic, carcinogenic, or nephrotoxic risk to humans. In humans, d-limonene has demonstrated low toxicity… 

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References

SHOWING 1-10 OF 44 REFERENCES

Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis.

d-Limonene was found to be effective in reducing the average number of rat mammary carcinomas that developed in 7,12-dimethylbenz[a]anthracene-treated rats when the terpene was fed during the

The male rat carcinogens limonene and sodium saccharin are not mutagenic to male Big Blue rats.

Assessing the mutagenic potential of the two chemicals to male lacI transgenic rats added further support to a non-genotoxic mechanism of carcinogenic action for both limonene and sodium saccharin.

The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors.

Whether or not dL causes sustained increases in cell proliferation and has promoting activity for renal adenomas in male rats and if the male rat-specific urinary protein, alpha 2u-G, is required is determined.

d-limonene chemoprevention of hepatocarcinogenesis in AKR mice: inhibition of c-jun and c-myc.

The present investigation explains the anti-tumour effect of d-limonene for the first time on the level of oncogene expression in NDEA and NDEa-PB mediated hepatocarcinogenesis.

The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil.

The monocyclic monoterpenoid d-limonene and its source, orange oil, were found to prevent rat mammary carcinomas induced by the direct-acting carcinogen nitrosomethylurea. This chemopreventive effect

Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee.

D-Limonene is well tolerated in cancer patients at doses which may have clinical activity and the favorable toxicity profile supports further clinical evaluation.

Studies on the metabolism of d-limonene (p-mentha-1,8-diene). I. The absorption, distribution and excretion of d-limonene in rats.

The absorption, distribution and excretion of d-limonene were investigated in rats using the 14C-labelled compound and radioactivity in liver, kidney and blood was higher than in other tissues, but was negligible 48 h after administration.

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils.

This study provides additional data demonstrating that non-nutrient constituents of the diet can inhibit carcinogen-induced neoplasia when administered at a short time interval prior to carcinogen challenge.

Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes.

The results of these studies provide evidence of an increasing diversity of naturally occurring compounds having the capacity to inhibit nitrosamine carcinogenesis.