Safety Evaluation And Risk Assessment Of d-Limonene

@article{Kim2013SafetyEA,
  title={Safety Evaluation And Risk Assessment Of d-Limonene},
  author={Y. Kim and M. Kim and B. Chung and Du Yeon Bang and S. K. Lim and S. M. Choi and D. Lim and Myung Chan Cho and K. Yoon and H. Kim and K. B. Kim and S. Kwack and B. Lee},
  journal={Journal of Toxicology and Environmental Health, Part B},
  year={2013},
  volume={16},
  pages={17 - 38}
}
  • Y. Kim, M. Kim, +11 authors B. Lee
  • Published 2013
  • Chemistry, Medicine
  • Journal of Toxicology and Environmental Health, Part B
d-Limonene, a major constituent of citrus oils, is a monoterpene widely used as a flavor/fragrance additive in cosmetics, foods, and industrial solvents as it possesses a pleasant lemon-like odor. d-Limonene has been designated as a chemical with low toxicity based upon lethal dose (LD50) and repeated-dose toxicity studies when administered orally to animals. However, skin irritation or sensitizing potential was reported following widespread use of this agent in various consumer products. In… Expand
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References

SHOWING 1-10 OF 136 REFERENCES
D-Limonene: safety and clinical applications.
  • Jidong Sun
  • Medicine
  • Alternative medicine review : a journal of clinical therapeutic
  • 2007
  • 320
  • Highly Influential
  • PDF
The human relevance of the renal tumor-inducing potential of d-limonene in male rats: implications for risk assessment.
  • 84
  • Highly Influential
Animal experiments on the allergenicity of d-limonene--the citrus solvent.
  • 61
  • Highly Influential
Assessment of the subchronic oral toxicity of d-limonene in dogs.
  • 29
  • Highly Influential
Additive toxicity of limonene and 50% oxygen and the role of glutathione in detoxification in human lung cells.
  • 29
Pharmacokinetics of d-limonene in the rat by GC-MS assay.
  • 17
Risk assessment of d-limonene: an example of male rat-specific renal tumorigens.
  • 53
d-limonene exposure to humans by inhalation: uptake, distribution, elimination, and effects on the pulmonary function.
  • 84
Oxidized citrus oil (R-limonene): a frequent skin sensitizer in Europe.
  • 108
  • Highly Influential
...
1
2
3
4
5
...