Safety Considerations of DNA in Food

@article{Jonas2001SafetyCO,
  title={Safety Considerations of DNA in Food},
  author={D. A. Jonas and Ibrahim Elmadfa and Karl-Heinz Engel and Knut J Heller and Gunhild Kozianowski and Ariane K{\"o}nig and D. M{\"u}ller and Jean François Narbonne and Wilfried Wackernagel and J. Kleiner},
  journal={Annals of Nutrition and Metabolism},
  year={2001},
  volume={45},
  pages={235 - 254}
}
Recombinant DNA techniques are capable of introducing genetic changes into food organisms that are more predictable than those introduced through conventional breeding techniques. This review discusses whether the consumption of DNA in approved novel foods and novel food ingredients derived from genetically modified organisms (GMOs) can be regarded as being as safe as the consumption of DNA in existing foods. It concludes that DNA from GMOs is equivalent to DNA from existing food organisms that… 
View on PubMed
karger.com
171 Citations
Highly Influential Citations
16
Background Citations
62
Methods Citations
6
Results Citations
3

Figures and Tables from this paper

171 Citations

Addressing concerns over the fate of DNA derived from genetically modified food in the human body: A review.
  • M. Nawaz, R. Mesnage, G. Chung
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2019
The Stability and Degradation of Dietary DNA in the Gastrointestinal Tract of Mammals: Implications for Horizontal Gene Transfer and the Biosafety of GMOs
TLDR
Despite the ability of several bacterial species to acquire external DNA by natural transformation, in vivo transfer of dietary DNA to bacteria in the intestine has not been detected in the few experimental studies conducted so far.
Safety assessment of food products from r-DNA animals.
  • M. Lema, M. Burachik
  • Biology
    Comparative immunology, microbiology and infectious diseases
  • 2009
Safety of Genetically Engineered Foods. Approaches to Assessing Unintended Health Effects
Detection of dietary DNA, protein, and glyphosate in meat, milk, and eggs.
TLDR
The available data do not provide evidence to suggest that products from animals that have consumed approved GE feed crops differ in any distinguishable way from those derived from animals fed conventional feed or that productsFrom animals fed GE feedstuffs pose novel health risks.
EFSA statement on the fate of recombinant DNA or proteins in meat , milk and eggs from animals fed with GM feed
  • 2007
Regulation (EC) No 1829/2003 on GM food and feed foresees labelling requirements. Decisions on labelling are taken by risk managers with the aim of offering the consumer an informed choice and are…
POSSIBILITIES AND DILEMMAS OF USING TRANSGENIC FOOD IN HUMAN NUTRITION
TLDR
Gene technology cannot solve all the problems of world nutrition but let this revolutionary method be legally applied.
Assessing the fate of recombinant plant DNA in rabbit's tissues fed genetically modified cotton.
TLDR
The results obtained from this study revealed that both plant endogenous and transgenic DNA fragments have same fate in rabbit's tissues and were efficiently degraded in the gastrointestinal tract (GIT).
Quantification of DNA from genetically modified organisms in composite and processed foods
Molecular Methods in Food Safety Microbiology: Interpretation and Implications of Nucleic Acid Detection.
TLDR
interpretation of the public health significance of positive results generated by nucleic acid detection methods warrants some additional consideration, and the future perspectives of molecular methods such as next-generation sequencing in diagnostic and source attribution food microbiology are reviewed.
...
...

References

SHOWING 1-10 OF 158 REFERENCES
Safety assessment of viable genetically modified micro-organisms used in food
TLDR
The guidelines for the safety evaluation of viable genetically modified micro-organisms used in food will be published together with the scientific aspects underpinning these guidelines in Food Biotechnology.
Uptake of foreign DNA from the environment: the gastrointestinal tract and the placenta as portals of entry.
TLDR
Food-ingested M13 DNA reaches peripheral white blood cells, the spleen and liver via the intestinal epithelia and cells in the Peyer's patches of the intestinal wall and it is likely that the M13DNA is transferred by the transplacental route and not via the germ line.
On the fate of orally ingested foreign DNA in mice: chromosomal association and placental transmission to the fetus
TLDR
This distribution pattern argues for a transplacental pathway rather than for germline transmission which might be expected only after long-time feeding regimens, and in rare cells of three different fetuses, whose mothers have been fed with M13 DNA during gestation, the foreign DNA was detected by FISH in association with both chromatids.
The fate of recombinant DNA in thermally treated fermented sausages
TLDR
No significant effect on the detectability of the rDNA was observed on variation of the ecological factors prevailing during the production and storage of the sausages, such as the temperature of thermal treatment, pH and fat content.
The fate of forage plant DNA in farm animals: a collaborative case-study investigating cattle and chicken fed recombinant plant material
TLDR
Data indicated that only short DNA fragments derived from plant chloroplasts could be detected in the blood lymphocytes of cows and in all other cattle organs investigated, and no foreign plant DNA fragments were found in eggs.
Foreign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be covalently linked to mouse DNA.
TLDR
Findings suggest transport of foreign DNA through the intestinal wall and Peyer's patches to peripheral blood leukocytes and into several organs in mice, suggesting medical and evolutionary implications of these observations may be considerable.
Fate of Free DNA and Transformation of the Oral Bacterium Streptococcus gordonii DL1 by Plasmid DNA in Human Saliva
TLDR
Findings indicate that DNA released from bacteria or food sources within the mouth has the potential to transform naturally competent oral bacteria, however, further investigations are needed to establish whether transformation of oral bacteria can occur at significant frequencies in vivo.
Nutrition Abstracts and Reviews Series B: Livestock Feeds and Feeding Safety issues associated with the DNA in animal feed derived from genetically modified crops. A review of scientific and regulatory procedures
TLDR
It is in this context, that the development and use of genetically modified (GM) crops could offer considerable potential and be a model for world food production.
Species differentiation of heated meat products by DNA hybridization.
Horizontal gene transfer from transgenic plants to terrestrial bacteria--a rare event?
TLDR
The few examples of HGT indicated by DNA sequence comparisons suggest that the frequencies of evolutionarily successful HGT from plants to bacteria may be extremely low, but this inference is based on a small number of experimental studies and indications found in the literature.
...
...