Safety Assessment of the Neomycin Phosphotransferase II (NPTII) Protein

@article{Fuchs1993SafetyAO,
  title={Safety Assessment of the Neomycin Phosphotransferase II (NPTII) Protein},
  author={Roy L. Fuchs and Joel E. Ream and Bruce G. Hammond and Mark W. Naylor and Richard M. Leimgruber and Sharon A. Berberich},
  journal={Bio/Technology},
  year={1993},
  volume={11},
  pages={1543-1547}
}
Two approaches were used to assess the safety of the NPTII protein for human consumption using purified E. coli produced NPTII protein that was shown to be chemically and functionally equivalent to the NPTII protein produced in genetically engineered cotton seed, potato tubers and tomato fruit. The NPTII protein was shown, as expected, to degrade rapidly under simulated mammalian digestive conditions. An acute mouse gavage study confirmed that the NPTII protein caused no deleterious effects… CONTINUE READING