Safety Aspects of the Use of Quercetin as a Dietary Supplement

@article{Andres2018SafetyAO,
  title={Safety Aspects of the Use of Quercetin as a Dietary Supplement},
  author={Susanne Andres and Sophie Pevny and Rainer Ziegenhagen and Nadiya Bakhiya and Bernd Sch{\"a}fer and Karen Ildico Hirsch‐Ernst and Alfonso Lampen},
  journal={Molecular Nutrition \& Food Research},
  year={2018},
  volume={62},
  pages={\&NA;}
}
The flavonoid quercetin is frequently found in low amounts as a secondary plant metabolite in fruits and vegetables. Isolated quercetin is also marketed as a dietary supplement, mostly as the free quercetin aglycone, and frequently in daily doses of up to 1000 mg d-1 exceeding usual dietary intake levels. The present review is dedicated to safety aspects of isolated quercetin used as single compound in dietary supplements. Among the numerous published human intervention studies, adverse effects… 

Figures from this paper

The Potential Toxic Side Effects of Flavonoids

Flavonoids are a class of phytochemical molecules abundant in many plants, fruits, vegetables, and leaves. Flavonoids possess a series of significant biological activities, including anticancer,

Quercetin as an antiinflammatory analgesic

Enhancing the Bioavailability of Quercetin by Concomitant Administration with Enzyme Inhibitor

Bioavailability of Quercetin will be increased by its administration together with ketoconazole, due to enzyme inhibiting effect of ketconazole which delay elimination and increase the AUC of QuERCetin.

An Overview of a Versatile Compound : Quercetin F Review

Flavonoids are phytochemical compounds found in a variety of plants, fruits, vegetables, leaves, and barks, it offers a wide range of health benefits. Quercetin is a polyphenolic flavonoid that is

Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus

It appears advisable to consider the potential health risks related to intake of isolated piperine in bolus form, e.g., when using certain food supplements, as well as the lack of investigation of the potentially adverse effects observed in animal studies and/or combined administration of p Piperine with other substances.

Dietary quercetin supplements: Assessment of online product informations and quantitation of quercetin in the products by high‐performance liquid chromatography

Because high‐quercetin content of dietary supplements was confirmed, health care professionals should be aware of the unregulated internet market of Dietary supplements and should consider the interactions of these substances with drugs.

Health Benefits of Quercetin in Age-Related Diseases

A detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out and it is proved that quercETin plays a crucial role in the prevention of age-related disorders.

Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies.

The evidence of most recent knowledge of anticonvulsant properties of quercetin and its derivatives on preclinical studies is provided and neuroprotective effect of these bioactive compound is discussed and underlying mechanisms responsible for anticonventrine properties are presented in brief.

Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced Hypertension: Review of In Vitro, In Vivo, and Clinical Studies

This review focuses on the selective activity of quercetin, a well-known flavonoid due to its antihypertensive action, that should be appreciated and studied in the aspect of its potential use in the prevention and treatment of pregnancy-induced hypertension among women in this risk group.
...

References

SHOWING 1-10 OF 160 REFERENCES

Safety of quercetin for clinical application (Review).

  • T. Okamoto
  • Biology, Medicine
    International journal of molecular medicine
  • 2005
In vitro studies indicate that quercetin is protective against genotoxicants, and regarded as antimutagenic, and its safety upon human application is approved.

Health effects of quercetin: from antioxidant to nutraceutical.

Pharmacokinetics and bioavailability of the flavonol quercetin in humans.

In vivo data on the disposition, absorption, bioavailability, and metabolism of quercetin after intravenous and oral administration in humans are scarce and contradictory, and insufficient to clarify whether or not quercETin can be held responsible for any protective or curative effect observed after oral intake.

Pharmacokinetics and Bioavailability of Quercetin Glycosides in Humans

The disposition of quercetin in humans primarily depends on the sugar moiety, and to a minor extent, the plant matrix influences both the rate and extent of absorption in the case of buckwheat tea administration compared with the isolated compound.

Tissue distribution of quercetin in rats and pigs.

These studies have for the first time identified target tissues of quercetin, which may help to understand its mechanisms of action in vivo, and identify its availability to tissues.

Tissue distribution of quercetin in pigs after long-term dietary supplementation.

Long-term dietary intake of the flavonol did not lead to a greater accumulation in any tissue compared with the single treatment, and the specific beta-glucuronidase activity was not correlated with the proportions of deconjugated flavonols in the various tissues.

A–Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance—Part 33

Another intriguing plant-based compound with proposed benefits as an antioxidant and stimulator of mitochondrial biogenesis, resveratrol is covered, and Rhodiola rosea, a claimed adaptogen, concludes this issue.
...