Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers.

@article{Le2000SafetyTA,
  title={Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers.},
  author={Thuan P. Le and Kevin M. Coonan and Richard C. Hedstrom and Yupin Charoenvit and Martha Sedegah and Judith E. Epstein and Sanjai Kumar and Ruobing Wang and Denise L. Doolan and Jason D. Maguire and Suezanne E. Parker and Peter M. Hobart and J A Norman and Stephen L Hoffman},
  journal={Vaccine},
  year={2000},
  volume={18 18},
  pages={1893-901}
}
DNA-based vaccines are considered to be potentially revolutionary due to their ease of production, low cost, long shelf life, lack of requirement for a cold chain and ability to induce good T-cell responses. Twenty healthy adult volunteers were enrolled in a Phase I safety and tolerability clinical study of a DNA vaccine encoding a malaria antigen. Volunteers received 3 intramuscular injections of one of four different dosages (20, 100, 500 and 2500 microg) of the Plasmodium falciparum… CONTINUE READING

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