Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects

@article{CohenBarak2015SafetyPA,
  title={Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects},
  author={O. Cohen-Barak and Jacqueline A L Wildeman and J. van de Wetering and J. Hettinga and P. Schuilenga-Hut and A. Gross and S. Clark and M. Bassan and Y. Gilgun-Sherki and B. Mendzelevski and O. Spiegelstein},
  journal={Journal of Clinical Pharmacology},
  year={2015},
  volume={55},
  pages={573 - 583}
}
Human plasma butyrylcholinesterase (BChE) contributes to cocaine metabolism and has been considered for use in treating cocaine addiction and cocaine overdose. TV‐1380 is a recombinant protein composed of the mature form of human serum albumin fused at its amino terminus to the carboxy‐terminus of a truncated and mutated BChE. In preclinical studies, TV‐1380 has been shown to rapidly eliminate cocaine in the plasma thus forestalling entry of cocaine into the brain and heart. Two randomized… Expand
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