Safety, efficacy and pharmacokinetics of peginterferon alpha2a (40 kd) in children with chronic hepatitis C.

@article{Schwarz2006SafetyEA,
  title={Safety, efficacy and pharmacokinetics of peginterferon alpha2a (40 kd) in children with chronic hepatitis C.},
  author={Kathleen B. Schwarz and Parvathi Mohan and Michael R. Narkewicz and Jean Pappas Molleston and S. Russell Nash and Sylvia Hu and Ka Wang and Jean Michel Gries},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={2006},
  volume={43 4},
  pages={499-505}
}
Chronic hepatitis C virus (HCV) infection in children is a problem affecting thousands of children worldwide. Although standard interferon (INF) has better efficacy in pediatric patients than in adults, results in children with genotype 1 are poor; response rates to combination treatment with standard INF and ribavirin are better but the treatment requires thrice-weekly injections. The improved antiviral efficacy of weekly pegylated interferons relative to standard interferons in adults with… CONTINUE READING

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