Safety, efficacy and anti-inflammatory activity of rho iso-alpha-acids from hops.

Abstract

A defined mixture of rho iso-alpha-acids (RIAA), a modified hop extract, was evaluated for anti-inflammatory efficacy and safety. RIAA inhibited LPS-stimulated PGE(2) formation with >200-fold selectivity of COX-2 (IC(50)=1.3 microg/ml) over COX-1 (IC(50)>289 microg/ml). This occurred only when RIAA was added prior to, but not post, LPS stimulation… (More)
DOI: 10.1016/j.phytochem.2008.02.001

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