Safety, Tolerability, and Pharmacokinetics of Therapeutic and Supratherapeutic Doses of Tramadol Hydrochloride in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Multiple-Ascending-Dose Study.

@article{Delemos2017SafetyTA,
  title={Safety, Tolerability, and Pharmacokinetics of Therapeutic and Supratherapeutic Doses of Tramadol Hydrochloride in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Multiple-Ascending-Dose Study.},
  author={Byron Delemos and H. M. Tim Richards and Joris Vandenbossche and Jay Ariyawansa and Jaya Sudha Natarajan and Binu J Alexander and T. B. Ramakrishna and Thomas Murtaugh and Hans-J{\"u}rgen Stahlberg},
  journal={Clinical pharmacology in drug development},
  year={2017},
  volume={6 6},
  pages={
          592-603
        }
}
This randomized, double-blind, parallel-group multiple-ascending-dose study evaluated the safety, tolerability, and pharmacokinetics of tramadol hydrochloride in healthy adults to inform dosage and design for a subsequent QT/QTc study. Healthy men and women, 18 to 45 years old (inclusive), were sequentially assigned to the tramadol 200, 400, or 600 mg/day… CONTINUE READING