Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in Senegal

@inproceedings{Mensah2016SafetyIA,
  title={Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in Senegal},
  author={Victorine Atanase Mensah and Aly Gueye and Magatte Ndiaye and Nick J Edwards and Danny Wright and Nicholas A. Anagnostou and Massamba Syll and Amy Ndaw and Annie Abiola and Carly M Bliss and Jules-François Gomis and Ines Petersen and Caroline Ogwang and Tandakha D Dieye and Nicola K. Viebig and Alison M. Lawrie and Rachel Roberts and Alfredo Nicosia and Babacar T. Faye and Oumar Gaye and Odile Y Leroy and Egeruan Babatunde Imoukhuede and Katie J Ewer and Philip Bejon and Adrian V S Hill and Badara Ciss{\'e}},
  booktitle={PloS one},
  year={2016}
}
Malaria transmission is in decline in some parts of Africa, partly due to the scaling up of control measures. If the goal of elimination is to be achieved, additional control measures including an effective and durable vaccine will be required. Studies utilising the prime-boost approach to deliver viral vectors encoding the pre-erythrocytic antigen ME-TRAP (multiple epitope thrombospondin-related adhesion protein) have shown promising safety, immunogenicity and efficacy in sporozoite challenge… CONTINUE READING
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