Safety, Immunogenicity and Dose Ranging of a New Vi-CRM197 Conjugate Vaccine against Typhoid Fever: Randomized Clinical Testing in Healthy Adults

@inproceedings{Damme2011SafetyIA,
  title={Safety, Immunogenicity and Dose Ranging of a New Vi-CRM197 Conjugate Vaccine against Typhoid Fever: Randomized Clinical Testing in Healthy Adults},
  author={Pierre van Damme and Froukje Kafeja and Alessandra Anemona and Venere Basile and Anne Katrin Hilbert and Ilse De Coster and Simona Rondini and Francesca Micoli and Rana M. Qasim Khan and Elisa Marchetti and Vito Di Cioccio and A Tova Saul and Laura B. Martin and A. Podda},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly worldwide, with more than 90% of the disease burden being reported from Asia. Epidemiological data show high disease incidence in young children and suggest that immunization programs should target children below two years of age: this is not possible with available vaccines. The Novartis Vaccines Institute for Global Health developed a conjugate vaccine (Vi-CRM₁₉₇) for infant vaccination… CONTINUE READING

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