• Biology, Medicine
  • Published in Nature Reviews Cancer 2011
  • DOI:10.1038/nrc3179

Safe harbours for the integration of new DNA in the human genome

@article{Sadelain2011SafeHF,
  title={Safe harbours for the integration of new DNA in the human genome},
  author={Michel Sadelain and Eirini P Papapetrou and Frederic D. Bushman},
  journal={Nature Reviews Cancer},
  year={2011},
  volume={12},
  pages={51-58}
}
Interactions between newly integrate DNA and the host genome limit the reliability and safety of transgene integration for therapeutic cell engineering and other applications. Although targeted gene delivery has made considerable progress, the question of where to insert foreign sequences in the human genome to maximize safety and efficacy has received little attention. In this Opinion article, we discuss 'genomic safe harbours' — chromosomal locations where therapeutic transgenes can integrate… CONTINUE READING

Figures, Tables, and Topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
SHOWING 1-10 OF 170 CITATIONS, ESTIMATED 58% COVERAGE

Programmable Nuclease-Based Integration into Novel Extragenic Genomic Safe Harbor Identified from Korean Population-Based CNV Analysis

  • Molecular therapy oncolytics
  • 2019
VIEW 5 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS
HIGHLY INFLUENCED

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.

  • Cancer cell
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2012
2019

CITATION STATISTICS

  • 7 Highly Influenced Citations

  • Averaged 32 Citations per year from 2017 through 2019

  • 15% Increase in citations per year in 2019 over 2018

References

Publications referenced by this paper.
SHOWING 1-10 OF 95 REFERENCES

A method to sequence and quantify DNA integration for monitoring outcome in gene therapy

T Brady
  • Nucleic Acids Res. 39,
  • 2011

Efficient recombinasemediated cassette exchange at the AAVS1 locus in human embryonic stem cells using baculoviral vectors

Ramachandra, J C.
  • Nucleic Acids Res. 39,
  • 2011

Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction

Gaspar, B H.
  • Sci. Transl. Med. 3,
  • 2011

Solving the problem of γ-retroviral vectors containing long terminal repeats.

  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2011