Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection.

@article{Watkins2017SafeRO,
  title={Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection.},
  author={Hannah C. Watkins and C. Rappazzo and J. Higgins and X. Sun and Nicole Brock and Annie Chau and A. Misra and Joseph P. B. Cannizzo and M. R. King and T. Maines and C. Leifer and G. Whittaker and M. DeLisa and D. Putnam},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2017},
  volume={25 4},
  pages={
          989-1002
        }
}
  • Hannah C. Watkins, C. Rappazzo, +11 authors D. Putnam
  • Published 2017
  • Biology, Medicine
  • Molecular therapy : the journal of the American Society of Gene Therapy
    • Recombinant, Escherichia coli-derived outer membrane vesicles (rOMVs), which display heterologous protein subunits, have potential as a vaccine adjuvant platform. One drawback to rOMVs is their lipopolysaccharide (LPS) content, limiting their translatability to the clinic due to potential adverse effects. Here, we explore a unique rOMV construct with structurally remodeled lipids containing only the lipid IVa portion of LPS, which does not stimulate human TLR4. The rOMVs are derived from a… CONTINUE READING
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    References

    SHOWING 1-10 OF 67 REFERENCES
    Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies
    • 58
    • PDF
    Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice.
    • 40
    • PDF
    Delivery of foreign antigens by engineered outer membrane vesicle vaccines
    • 175
    • PDF
    Immunization with Escherichia coli Outer Membrane Vesicles Protects Bacteria-Induced Lethality via Th1 and Th17 Cell Responses
    • 94
    • PDF
    Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles.
    • 60
    Mechanistic Insight into the TH1-Biased Immune Response to Recombinant Subunit Vaccines Delivered by Probiotic Bacteria-Derived Outer Membrane Vesicles
    • 26
    • PDF
    A lipidated form of the extracellular domain of influenza M2 protein as a self-adjuvanting vaccine candidate.
    • 15
    Virus-like Particles Containing Multiple M2 Extracellular Domains Confer Improved Cross-protection Against Various Subtypes of Influenza Virus.
    • Min-Chul Kim, J. Song, +4 authors S. Kang
    • Biology, Medicine
    • Molecular therapy : the journal of the American Society of Gene Therapy
    • 2013
    • 107
    Immunization with Outer Membrane Vesicles Displaying Designer Glycotopes Yields Class-Switched, Glycan-Specific Antibodies.
    • 24
    Engineered bacterial outer membrane vesicles with enhanced functionality.
    • 106