Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection.

@article{Watkins2017SafeRO,
  title={Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection.},
  author={Hannah C. Watkins and C. Rappazzo and J. Higgins and X. Sun and Nicole Brock and Annie Chau and A. Misra and Joseph P. B. Cannizzo and M. R. King and T. Maines and C. Leifer and G. Whittaker and M. DeLisa and D. Putnam},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2017},
  volume={25 4},
  pages={
          989-1002
        }
}
  • Hannah C. Watkins, C. Rappazzo, +11 authors D. Putnam
  • Published 2017
  • Biology, Medicine
  • Molecular therapy : the journal of the American Society of Gene Therapy
  • Recombinant, Escherichia coli-derived outer membrane vesicles (rOMVs), which display heterologous protein subunits, have potential as a vaccine adjuvant platform. One drawback to rOMVs is their lipopolysaccharide (LPS) content, limiting their translatability to the clinic due to potential adverse effects. Here, we explore a unique rOMV construct with structurally remodeled lipids containing only the lipid IVa portion of LPS, which does not stimulate human TLR4. The rOMVs are derived from a… CONTINUE READING
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