Sacroiliitis and severe disability due to isotretinoin therapy

  title={Sacroiliitis and severe disability due to isotretinoin therapy},
  author={Alexander P Rozin and Olga Kagna and Yizhak Shiller},
  journal={Rheumatology International},
We report a case of acute sacroiliitis with severe disability after only 3 weeks of isotretinoin therapy with graduate reduction of pain, limitation and muscle incompetence after discontinuation of the drug and ACTH-depo injection and Ethodolac therapy. Naranjo probability scale indicated a probable relationship between isotretinoin therapy and bilateral sacroiliitis. We discussed possible mechanisms of sacroiliitis and disability due to isotretinoin treatment. 

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