Brucellosis is a zoonotic disease which has a significant presence in endemic areas. The most important factors on the delay of the diagnosis and treatment are the vagueness of the systemic features and the inadequacy of laboratory and imaging methods to distinguish the disease from other pathological conditions. In this study, the challenges in the diagnosis and treatment are presented in a case of brucella spondylodiscitis, which is caused by a sacroiliac joint involvement following a surgery due to a lumbar disc herniation. Retrospective case analysis. After the confirmation of brucellosis the patient was put on antibiotic treatment. She responded well to antibiotic therapy with complete resolution of her symptoms. Clinically there is no specific symptom by which brucellosis can be surely recognized. Especially patients living in endemic countries which present with back or lower back pain of unknown origin, should be suspected of brucellosis.