Sacral insufficiency fractures after preoperative chemoradiation for rectal cancer: incidence, risk factors, and clinical course.

@article{Herman2009SacralIF,
  title={Sacral insufficiency fractures after preoperative chemoradiation for rectal cancer: incidence, risk factors, and clinical course.},
  author={Michael P. Herman and Scott Kopetz and Priya Ranjit Bhosale and Cathy Eng and John Michael Skibber and Miguel Rodriguez-Bigas and Barry Feig and George Chang and Marc E. Delclos and Sunil Krishnan and Christopher H. Crane and Prajnan Das},
  journal={International journal of radiation oncology, biology, physics},
  year={2009},
  volume={74 3},
  pages={818-23}
}
PURPOSE Sacral insufficiency (SI) fractures can occur as a late side effect of pelvic radiation therapy. Our goal was to determine the incidence, risk factors, and clinical course of SI fractures in patients treated with preoperative chemoradiation for rectal cancer. MATERIALS AND METHODS Between 1989 and 2004, 562 patients with non-metastatic rectal adenocarcinoma were treated with preoperative chemoradiation followed by mesorectal excision. The median radiotherapy dose was 45 Gy. The… CONTINUE READING
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