Sacituzumab Govitecan‐hziy in Refractory Metastatic Triple‐Negative Breast Cancer

@article{Bardia2019SacituzumabGI,
  title={Sacituzumab Govitecan‐hziy in Refractory Metastatic Triple‐Negative Breast Cancer},
  author={Aditya Bardia and Ingrid A. Mayer and Linda T Vahdat and Sara M. Tolaney and Steven J. Isakoff and Jennifer R. Diamond and Joyce O’Shaughnessy and Rebecca L. Moroose and Alessandro D. Santin and Vandana G. Abramson and Nikita C. Shah and Hope S. Rugo and David M. Goldenberg and Alaa Sweidan and R. Iannone and Sarah A. Washkowitz and Robert M Sharkey and William A. Wegener and Kevin Kalinsky},
  journal={The New England Journal of Medicine},
  year={2019},
  volume={380},
  pages={741–751}
}
BACKGROUND Standard chemotherapy is associated with low response rates and short progression‐free survival among patients with pretreated metastatic triple‐negative breast cancer. Sacituzumab govitecan‐hziy is an antibody–drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell‐surface antigen 2 (Trop‐2), with SN‐38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan‐hziy enables delivery of high concentrations of SN‐38… 

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  • A. Bardia
  • Medicine
    Clinical advances in hematology & oncology : H&O
  • 2020
This agent delivers high doses of the antineoplastic drug SN-38 to cancer cells, while relatively sparing noncancerous cells, and should be considered a new standard of care in patients with pretreated, metastatic triple-negative breast cancer.
...

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