Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination.

@article{Shinohara1997SaccharomycesCR,
  title={Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination.},
  author={Akira Shinohara and Stephen L. Gasior and Tohru Ogawa and Nancy Kleckner and Douglas K. Bishop},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={1997},
  volume={2 10},
  pages={615-29}
}
BACKGROUND Rad51 and Dmc1 are Saccharomyces cerevisiae homologues of the Escherichia coli recombination protein RecA. Mutant analysis has shown that both proteins are required for normal meiotic recombination, for timely and efficient formation of synaptonemal complex and for normal progression out from meiotic prophase. RESULTS We have further characterized rad51 and dmc1 single mutants. A dmc1 mutation confers more severe defects in double strand break (DSB) resolution, crossover… CONTINUE READING

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