Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant.

@article{Vargas2004SaccharomycesCM,
  title={Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant.},
  author={Rita C Vargas and Sandra Tenreiro and Miguel C. Teixeira and Alexandra R. Fernandes and Isabel S{\'a}-Correia},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 7},
  pages={2531-7}
}
This work reports the functional analysis of Saccharomyces cerevisiae open reading frame YIL121w, encoding a member of a family of drug:H(+) antiporters with 12 predicted membrane-spanning segments (DHA12 family). Like its close homologue Qdr1p, Yil121wp was localized at the plasma membrane, and its increased expression also led to increased tolerance to the antiarrhythmia and antimalarial drug quinidine. The quinidine resistance phenotype was confirmed for different yeast strains and growth… CONTINUE READING
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