Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats.

@article{Mannaa2005SaccharomycesCI,
  title={Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats.},
  author={Fathia A. Mannaa and Hanaa Hamdy Ahmed and Selim F. Estefan and Hafiza A. Sharaf and Emad Fawzi Eskander},
  journal={Die Pharmazie},
  year={2005},
  volume={60 9},
  pages={689-95}
}
The aim of this work was to investigate the protective role of baker's yeast Saccharomyces cerevisiae against the hepatotoxic effect of the drug flutamide that is widely used for treatment of metastatic prostate adenocarcinoma. Administration of flutamide to adult male rats in a dose of 100 mg/kg b.w. daily for 15 days resulted in serious hepatic injury. Highly significant increase in each of serum ALT, ALP, bilirubin, bile acids and cholesterol level, relative to the control group, was… CONTINUE READING
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