Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability.

@article{Myung2003SaccharomycesCC,
  title={Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability.},
  author={Kyungjae Myung and Vincent Pennaneach and Ellen S Kats and Richard D Kolodner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 11},
  pages={6640-5}
}
Some spontaneous gross chromosomal rearrangements (GCRs) seem to result from DNA-replication errors. The chromatin-assembly factor I (CAF-I) and replication-coupling assembly factor (RCAF) complexes function in chromatin assembly during DNA replication and repair and could play a role in maintaining genome stability. Inactivation of CAF-I or RCAF increased the rate of accumulating different types of GCRs including translocations and deletion of chromosome arms with associated de novo telomere… CONTINUE READING
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