Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.

@article{Bhattacharyya2004SaccharomycesCS,
  title={Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.},
  author={Saumitri Bhattacharyya and Robert S. Lahue},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 17},
  pages={7324-30}
}
Trinucleotide repeats (TNRs) undergo frequent mutations in families afflicted with certain neurodegenerative disorders and in model organisms. TNR instability is modulated both by the repeat tract itself and by cellular proteins. Here we identified the Saccharomyces cerevisiae DNA helicase Srs2 as a potent and selective inhibitor of expansions. srs2 mutants… CONTINUE READING