Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis.

@article{Cipollina2008SaccharomycesCS,
  title={Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis.},
  author={Chiara Cipollina and Joost van den Brink and Pascale A. S. Daran-Lapujade and Jack T. Pronk and Danilo Porro and Johannes H. de Winde},
  journal={Microbiology},
  year={2008},
  volume={154 Pt 6},
  pages={
          1686-99
        }
}
Saccharomyces cerevisiae SFP1 is required for nutrient-dependent regulation of ribosome biogenesis and cell size. A mutant deleted for SFP1 shows specific traits, including a slow growth phenotype, especially when growing on glucose. We recently analysed the physiology of an sfp1Delta mutant and its isogenic reference strain in chemostat cultures. This approach was successful in revealing the effects of nutrients on the activity of Sfp1 independent of growth rate-related feedback. In the… CONTINUE READING

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