Saccharomyces cerevisiae RRM3, a 5' to 3' DNA helicase, physically interacts with proliferating cell nuclear antigen.

@article{Schmidt2002SaccharomycesCR,
  title={Saccharomyces cerevisiae RRM3, a 5' to 3' DNA helicase, physically interacts with proliferating cell nuclear antigen.},
  author={Kristina Hildegard Schmidt and Katrina L Derry and Richard D Kolodner},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 47},
  pages={
          45331-7
        }
}
Proliferating cell nuclear antigen (PCNA) plays an essential role in eukaryotic DNA replication, and numerous DNA replication proteins have been found to interact with PCNA through a conserved eight-amino acid motif called the PIP-box. We have searched the genome of the yeast Saccharomyces cerevisiae for open reading frames that encode proteins with putative PIP-boxes and initiated testing of 135 novel candidates for their ability to interact with PCNA-conjugated agarose beads. The first new… CONTINUE READING
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