Saccharomyces cerevisiae Hrq1 requires a long 3'-tailed DNA substrate for helicase activity.

@article{Kwon2012SaccharomycesCH,
  title={Saccharomyces cerevisiae Hrq1 requires a long 3'-tailed DNA substrate for helicase activity.},
  author={Sung-Hun Kwon and Do-Hee Choi and Rina Yin Ling Lee and Sung-Ho Bae},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={427 3},
  pages={
          623-8
        }
}
RecQ helicases are well conserved proteins from bacteria to human and function in various DNA metabolism for maintenance of genome stability. Five RecQ helicases are found in humans, whereas only one RecQ helicase has been described in lower eukaryotes. However, recent studies predicted the presence of a second RecQ helicase, Hrq1, in fungal genomes and verified it as a functional gene in fission yeast. Here we show that 3'-5' helicase activity is intrinsically associated with Hrq1 of… CONTINUE READING
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