Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway.

@article{Izquierdo2008SaccharomycesCG,
  title={Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway.},
  author={Alicia Izquierdo and Celia Casas and Ulrich M{\"u}hlenhoff and Christopher Horst Lillig and Enrique Montero Herrero},
  journal={Eukaryotic cell},
  year={2008},
  volume={7 8},
  pages={1415-26}
}
Saccharomyces cerevisiae Grx6 and Grx7 are two monothiol glutaredoxins whose active-site sequences (CSYS and CPYS, respectively) are reminiscent of the CPYC active-site sequence of classical dithiol glutaredoxins. Both proteins contain an N-terminal transmembrane domain which is responsible for their association to membranes of the early secretory pathway vesicles, facing the luminal side. Thus, Grx6 localizes at the endoplasmic reticulum and Golgi compartments, while Grx7 is mostly at the… CONTINUE READING

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