Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.

@article{BeckerKettern2016SaccharomycesCF,
  title={Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.},
  author={Julia Becker-Kettern and Nicole Paczia and Jean-François Conrotte and Daniel P. Kay and C{\'e}dric Guignard and Paul P Jung and Carole L. Linster},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 12},
  pages={6036-58}
}
The D or L form of 2-hydroxyglutarate (2HG) accumulates in certain rare neurometabolic disorders, and high D-2-hydroxyglutarate (D-2HG) levels are also found in several types of cancer. Although 2HG has been detected in Saccharomyces cerevisiae, its metabolism in yeast has remained largely unexplored. Here, we show that S. cerevisiae actively forms the D enantiomer of 2HG. Accordingly, the S. cerevisiae genome encodes two homologs of the human D-2HG dehydrogenase: Dld2, which, as its human… CONTINUE READING