Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin.

@article{Frohloff2001SaccharomycesCE,
  title={Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin.},
  author={Frank Frohloff and Lars Fichtner and Daniel Jablonowski and Karin D Breunig and Raffael Schaffrath},
  journal={The EMBO journal},
  year={2001},
  volume={20 8},
  pages={
          1993-2003
        }
}
Kluyveromyces lactis killer strains secrete a zymocin complex that inhibits proliferation of sensitive yeast genera including Saccharomyces cerevisiae. In search of the putative toxin target (TOT), we used mTn3:: tagging to isolate zymocin-resistant tot mutants from budding yeast. Of these we identified the TOT1, TOT2 and TOT3 genes (isoallelic with ELP1, ELP2 and ELP3, respectively) coding for the histone acetyltransferase (HAT)-associated Elongator complex of RNA polymerase II holoenzyme… CONTINUE READING

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