Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions.

@article{Rad1995SaccharomycesCA,
  title={Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions.},
  author={Massoud Ramezani Rad and Huan L. Phan and Lutz Kirchrath and Philip K. Tan and Tomas Kirchhausen and Cornelis P. Hollenberg and Gregory S Payne},
  journal={Journal of cell science},
  year={1995},
  volume={108 ( Pt 4)},
  pages={1605-15}
}
Clathrin-coated vesicles mediate selective intracellular protein traffic from the plasma membrane and the trans-Golgi network. At these sites, clathrin-associated protein (AP) complexes have been implicated in both clathrin coat assembly and collection of cargo into nascent vesicles. We have found a gene on yeast chromosome XI that encodes a homologue of the mammalian AP beta subunits. Disruptions of this gene, APl2, and a previously identified beta homologue, APl1, have been engineered in… CONTINUE READING

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