Saccharomyces cerevisiae: gene annotation and genome variability, state of the art through comparative genomics.

@article{Louis2011SaccharomycesCG,
  title={Saccharomyces cerevisiae: gene annotation and genome variability, state of the art through comparative genomics.},
  author={Edward J Louis},
  journal={Methods in molecular biology},
  year={2011},
  volume={759},
  pages={31-40}
}
In the early days of the yeast genome sequencing project, gene annotation was in its infancy and suffered the problem of many false positive annotations as well as missed genes. The lack of other sequences for comparison also prevented the annotation of conserved, functional sequences that were not coding. We are now in an era of comparative genomics where many closely related as well as more distantly related genomes are available for direct sequence and synteny comparisons allowing for more… CONTINUE READING

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