Saccharin increases the effectiveness of glucose in stimulating ingestion in rats but has little effect on negative feedback.

@article{Breslin1996SaccharinIT,
  title={Saccharin increases the effectiveness of glucose in stimulating ingestion in rats but has little effect on negative feedback.},
  author={Paul A S Breslin and John R. Davis and R Rosenak},
  journal={Physiology & behavior},
  year={1996},
  volume={60 2},
  pages={411-6}
}
To determine if oropharyngeal stimulation contributes to the magnitude of the negative feedback signal during ingestion, we tested rats on a series of solutions that varied in taste intensity but not in nutritive or osmotic properties. To do this, Na saccharin was added to a standard 0.2 M glucose solution in concentrations of 0, 0.25, 0.5, 1, 2, 4, and 8 mM. Nondeprived rats were given free access to these solutions in ascending order of concentration in 30-min tests in test cages with a… CONTINUE READING

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