Saccharide-RNA recognition in a complex formed between neomycin B and an RNA aptamer.

@article{Jiang1999SaccharideRNARI,
  title={Saccharide-RNA recognition in a complex formed between neomycin B and an RNA aptamer.},
  author={Licong Jiang and A. P. Nandi Majumdar and Weidong Hu and T J Jaishree and Wenlian Xu and Dinshaw J. Patel},
  journal={Structure},
  year={1999},
  volume={7 7},
  pages={817-27}
}
BACKGROUND Aminoglycoside antibiotics can target RNA folds with micromolar affinity and inhibit biological processes ranging from protein biosynthesis to ribozyme action and viral replication. Specific features of aminoglycoside antibiotic-RNA recognition have been probed using chemical, biochemical, spectroscopic and computational approaches on both natural RNA targets and RNA aptamers identified through in vitro selection. Our previous studies on tobramycin-RNA aptamer complexes are extended… CONTINUE READING
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