Saccadic Eye Movement Characteristics in Adult Niemann-Pick Type C Disease: Relationships with Disease Severity and Brain Structural Measures

@inproceedings{Abel2012SaccadicEM,
  title={Saccadic Eye Movement Characteristics in Adult Niemann-Pick Type C Disease: Relationships with Disease Severity and Brain Structural Measures},
  author={Larry Abel and Elizabeth A Bowman and Dennis Velakoulis and Michael C. Fahey and Patricia Desmond and Matthew Duncan Macfarlane and Jeffrey Chee Leong Looi and Christopher L. Adamson and Mark Walterfang},
  booktitle={PloS one},
  year={2012}
}
Niemann-Pick Type C disease (NPC) is a rare genetic disorder of lipid metabolism. A parameter related to horizontal saccadic peak velocity was one of the primary outcome measures in the clinical trial assessing miglustat as a treatment for NPC. Neuropathology is widespread in NPC, however, and could be expected to affect other saccadic parameters. We compared horizontal saccadic velocity, latency, gain, antisaccade error percentage and self-paced saccade generation in 9 adult NPC patients to… CONTINUE READING

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