Saccade and cognitive impairment associated with kava intoxication

  title={Saccade and cognitive impairment associated with kava intoxication},
  author={Sheree Cairney and Paul Maruff and Alan R. Clough and Alex Collie and Jon Currie and Bart J. Currie},
  journal={Human Psychopharmacology: Clinical and Experimental},
Kava is an extract from the Piper methysticum Forst. f. plant that has social and spiritual importance in Pacific islands societies. Herbal remedies that contain kava are used for the psychiatric treatment of anxiety and insomnia. Laboratory studies have found only subtle, if any, changes on cognitive or motor functions from the acute effects of consuming small clinical doses of kava products. Intoxication from recreational doses of kava has not been studied. The performance of individuals… 
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Saccade and Cognitive Function in Chronic Kava Users
Current and ex-kava users showed a higher rate of kava dermopathy, lower body mass index, lowered blood lymphocytes and, in addition, current kavausers showed elevated liver enzymes, while there has recently been increasing concern about potentially fatal liver damage attributed to kava use.
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The context in which kava is used is considered, together with its underlying psychopharmacological mechanisms, to investigate the neurobehavioural effects associated with kava use to gain an understanding of its immediate neuropsychiatric effects and long-term cognitive effects.
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The present findings suggest that kava alone has little effect on reported condition and cognitive performance, but appears to potentiate both perceived and measured impairment when combined with alcohol.
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Acute effects of kava on measures of cognitive performance, physiological function and mood.
Volunteer subjects were assigned to receive a mixture of the intoxicating substance, kava, in a mixture with fruit juice, or juice alone. Subjects then undertook tasks of acute cognitive functioning,
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Twelve healthy volunteers were tested in a double-blind crossover study to assess the effects of oxazepam and an extract of kava roots (Piper methysticum) on behavior and event-related potentials
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Brain maps of drug induced pharmaco‐EEG changes demonstrated that kavain exerted a significant action on the human brain function as compared with placebo characterized by a dose‐dependent increase of delta, theta and alpha 1 activity while alpha 2, beta activity and the centroid of the total activity decreased.
Eye movement effects of diazepam in sons of alcoholic fathers and male control subjects.
Sons of alcoholic fathers and male controls without a family history of alcoholism displayed significantly less diazepam effects on peak saccade velocity, average smooth pursuit gain, memory, and self-rated sedation, but significantly greater pleasurable drug effects.
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Does kava cause hallucinations in Aboriginal populations in eastern Arnhem Land (Australia)
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