SYNTHETIC STUDIES TOWARD HENNOXAZOLE A. USE OF A SELECTIVE BISOXAZOLE ALKYLATION AS THE KEY FRAGMENT COUPLING

@article{Smith2002SYNTHETICST,
  title={SYNTHETIC STUDIES TOWARD HENNOXAZOLE A. USE OF A SELECTIVE BISOXAZOLE ALKYLATION AS THE KEY FRAGMENT COUPLING},
  author={Thomas E. Smith and Emily P. Balskus},
  journal={Heterocycles},
  year={2002},
  volume={57},
  pages={1219-1225}
}
A model system for side chain fragment coupling to the core of hennoxazole A is investigated. Lateral metallation of a C 1 3 -TBS-protected bisoxazole, using lithium diethylamide, allows for selective and efficient alkylation at C 1 5 . 
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Recent advances in the total syntheses of oxazole-containing natural products
Alkylation of 2-substituted (6-methyl-2-pyridyl)methyllithium species with epoxides.
TLDR
The trisubstituted epoxide gave low yields of adducts with all (2-pyridyl)methyllithium species studied and this results are discussed in the context of a proposed synthesis of cananodine.
Potential biotechnological capabilities of cultivable mycobiota from carwash effluents
TLDR
It is demonstrated that fungi from carwash effluents are natural sources of some biotechnologically important products and have potential for application in bioremediation of hydrocarbon polluted sites.
Synthetic Studies Toward Hennoxazole A. Use of a Selective Bisoxazole Alkylation as the Key Fragment Coupling.

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