SYNTHESIS AND ANTITUMOR ACTIVITY OF 5-BROMO-1-MESYLURACIL

@article{GlavaObrovac2005SYNTHESISAA,
  title={SYNTHESIS AND ANTITUMOR ACTIVITY OF 5-BROMO-1-MESYLURACIL},
  author={Ljubica Glava{\vs}-Obrovac and Ivan Karner and Marina Pavlak and Marko Rada{\vc}i{\'c} and Jelena Ka{\vs}nar-{\vS}amprec and Biserka Žini{\'c}},
  journal={Nucleosides, Nucleotides \& Nucleic Acids},
  year={2005},
  volume={24},
  pages={557 - 569}
}
Large-scale preparation of 5-bromo-1-mesyluracil (BMsU) 4 has been optimized. BMsU was synthesized by condensation of silylated 5-bromouracil and MsCl in acetonitrile or by the reaction of 5-bromouracil with MsCl in pyridine. The same product was obtained by bromination of 1-mesyluracil. The purpose of this study was to elucidate the effects of BMsU on the biosynthetic activity of tumor cell enzymes involved in DNA, RNA and protein syntheses, and in de novo and salvage pyrimidine and purine… 
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