Corpus ID: 88267909

SYNTHESIS AND ANTIANAPHYLACTIC ACTION OF 4-QUINOLONE-2-CARBOXYLIC ACID DERIVATIVES

@article{He1984SYNTHESISAA,
  title={SYNTHESIS AND ANTIANAPHYLACTIC ACTION OF 4-QUINOLONE-2-CARBOXYLIC ACID DERIVATIVES},
  author={L. He},
  journal={Acta pharmaceutica Sinica},
  year={1984}
}
  • L. He
  • Published 1984
  • Chemistry
  • Acta pharmaceutica Sinica
A series of 7-or 5,8-substituted 4-quinolone-2-carboxylic acid was synthesized and tested in rats for passive cutaneous anaphylaxis (PCA) assay as potential antiallergic agents. 7-Oxaloxy-4-quinolone-2-carboxylic acid (24) and 5-amino-4-quinolone-2-carboxylic acid (18) were shown to give 98.5% and 93.3% protection, respectively.