SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia

@inproceedings{Uckun2014SYKAA,
  title={SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia},
  author={Fatih M. Uckun and Sanjive Qazi},
  booktitle={Journal of cancer therapy},
  year={2014}
}
The identification of SYK as a master regulator of apoptosis controlling the activation of the PI3-K/AKT, NFκB, and STAT3 pathways-three major anti-apoptotic signaling pathways in B-lineage leukemia/lymphoma cells-prompts the hypothesis that rationally designed inhibitors targeting SYK may overcome the resistance of malignant B-lineage lymphoid cells to apoptosis and thereby provide the foundation for more effective multi-modality treatment regimens for poor prognosis B-precursor acute… CONTINUE READING

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