SWI/SNF nucleosome remodellers and cancer

  title={SWI/SNF nucleosome remodellers and cancer},
  author={Boris G. Wilson and Charles W. M. Roberts},
  journal={Nature Reviews Cancer},
SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel nucleosomes and to modulate transcription. Growing evidence indicates that these complexes have a widespread role in tumour suppression, as inactivating mutations in several SWI/SNF subunits have recently been identified at a high frequency in a variety of cancers. However, the mechanisms by which mutations in these complexes drive tumorigenesis are unclear. In this Review we discuss the contributions of SWI/SNF… CONTINUE READING
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