SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.

@article{Cohet2010SWISNFCR,
  title={SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.},
  author={Nathalie Cohet and Kathleen M. Stewart and Rajini Mudhasani and Ananthi J. Asirvatham and Chandrashekara Mallappa and Karen M. Imbalzano and Valerie M. Weaver and Anthony N. Imbalzano and Jeffrey A. Nickerson},
  journal={Journal of cellular physiology},
  year={2010},
  volume={223 3},
  pages={667-78}
}
The ATPase subunits of the SWI/SNF chromatin remodeling enzymes, Brahma (BRM) and Brahma-related gene 1 (BRG1), can induce cell cycle arrest in BRM and BRG1 deficient tumor cell lines, and mice heterozygous for Brg1 are pre-disposed to breast tumors, implicating loss of BRG1 as a mechanism for unregulated cell proliferation. To test the hypothesis that loss of BRG1 can contribute to breast cancer, we utilized RNA interference to reduce the amounts of BRM or BRG1 protein in the nonmalignant… CONTINUE READING