SWAP-70 is important for invasive phenotypes of mouse embryo fibroblasts transformed by v-Src.

@article{Murugan2008SWAP70II,
  title={SWAP-70 is important for invasive phenotypes of mouse embryo fibroblasts transformed by v-Src.},
  author={Avaniyapuram Kannan Murugan and Sayoko Ihara and Emi Y. Tokuda and Kimio Uematsu and Nobuo Tsuchida and Yasuhisa Fukui},
  journal={IUBMB life},
  year={2008},
  volume={60 4},
  pages={236-40}
}
SWAP-70 is a protein involved in actin rearrangement, especially in membrane ruffling. Mouse embryo fibroblasts (MEFs) deficient in SWAP-70 show impaired membrane ruffling and fail to grow in soft agar after transformation by v-Src. Here, we show that v-Src transformed MEFs expressing SWAP-70 are highly invasive. MEFs expressing SWAP-70 or v-Src alone were far less invasive, suggesting that both proteins were required for the cells to be invasive. Expression of both SWAP-70 and v-Src induced… CONTINUE READING