SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis

@article{Uchinaka2015SVVYGLRMO,
  title={SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis},
  author={A. Uchinaka and Y. Hamada and S. Mori and S. Miyagawa and A. Saito and Y. Sawa and N. Matsuura and H. Yamamoto and N. Kawaguchi},
  journal={Molecular and Cellular Biochemistry},
  year={2015},
  volume={408},
  pages={191-203}
}
Osteopontin (OPN) is involved in various physiological processes such as inflammatory and wound healing. However, little is known about the effects of OPN on these tissues. OPN is cleaved by thrombin, and cleavage of the N-terminal fragment exposes a SVVYGLR sequence on its C-terminus. In this study, we examined the effects of the thrombin-cleaved OPN fragments on fibroblasts and myocardial fibrosis, particularly the role of the SVVYGLR sequence. The recombinant thrombin-cleaved OPN fragments… Expand
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