SVCT1 and SVCT2: key proteins for vitamin C uptake

  title={SVCT1 and SVCT2: key proteins for vitamin C uptake},
  author={Isabella Savini and Antonello Rossi and Cristina Pierro and Luciana Avigliano and M Valeria Catani},
  journal={Amino Acids},
Summary.Vitamin C is accumulated in mammalian cells by two types of proteins: sodium-ascorbate co-transporters (SVCTs) and hexose transporters (GLUTs); in particular, SVCTs actively import ascorbate, the reduced form of this vitamin.SVCTs are surface glycoproteins encoded by two different genes, very similar in structure. They show distinct tissue distribution and functional characteristics, which indicate different physiological roles. SVCT1 is involved in whole-body homeostasis of vitamin C… 
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  • J. M. May
  • Biology
    British journal of pharmacology
  • 2011
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