SVCT1 and SVCT2: key proteins for vitamin C uptake

@article{Savini2007SVCT1AS,
  title={SVCT1 and SVCT2: key proteins for vitamin C uptake},
  author={I. Savini and A. Rossi and C. Pierro and L. Avigliano and M. Catani},
  journal={Amino Acids},
  year={2007},
  volume={34},
  pages={347-355}
}
Summary.Vitamin C is accumulated in mammalian cells by two types of proteins: sodium-ascorbate co-transporters (SVCTs) and hexose transporters (GLUTs); in particular, SVCTs actively import ascorbate, the reduced form of this vitamin.SVCTs are surface glycoproteins encoded by two different genes, very similar in structure. They show distinct tissue distribution and functional characteristics, which indicate different physiological roles. SVCT1 is involved in whole-body homeostasis of vitamin C… Expand
Redox regulation of vitamin C transporter SVCT2 in C2C12 myotubes.
TLDR
The redox-sensitive SVCT2 expression can be placed among the adaptive responses induced by contractile activity, and could be relevant in skeletal muscle, where reactive oxygen species, naturally produced during physical exercise, can induce muscle damage. Expand
Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge
TLDR
An overview of the current, limited knowledge of ascorbate transport across membranes, as well as tissue distribution, gene expression, and the relevance of SVCTs in cancer is given. Expand
The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C
  • J. M. May
  • Biology, Medicine
  • British journal of pharmacology
  • 2011
TLDR
Findings confirm the importance both of cellular ascorbate and of the two transport proteins as key to maintaining intracellular asCorbate. Expand
Sodium‐dependent vitamin C transporter 2 (SVCT2) is necessary for the uptake of L‐ascorbic acid into Schwann cells
TLDR
Evidence is provided for the first time that uptake of ascorbic acid in the peripheral nervous system is crucially dependent on the expression and activity of SVCT1 and 2. Expand
I Can C Clearly Now: How EPEC Inhibits Gut Vitamin C Transport by Dysregulating SVCT
TLDR
Clinical trials have been initiated in order to investigate the therapeutic effects of vitamin C administration as an adjunct to conventional therapy in patients with COVID-19 pneumonia (NCT04323514). Expand
Investigation of the potential molecular recognition sites of two human vitamin C transporters.
TLDR
This study could indicate regions on the amino acid sequences which could be fundamental for functionality for the two carriers of vitamin C, which would assist the growth of therapeutic strategies in fighting certain conditions and even in the production of new drugs. Expand
Sodium-coupled vitamin C transporter (SVCT2): expression, function, and regulation in intervertebral disc cells.
TLDR
It is demonstrated that the active SVCT2 is expressed in IVD cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone and its regulation by insulin-like growth factor 1 (IGF-1) and the steroid hormone dexamETHasone. Expand
Basic Science Sodium-coupled vitamin C transporter (SVCT2): expression, function, and regulation in intervertebral disc cells
BACKGROUND CONTEXT: Vitamin C (ascorbic acid [AA]) is essential for the synthesis of collagen and also acts as an antioxidant in the intervertebral disc (IVD). However, there is very littleExpand
Vitamin C Transporters and Their Implications in Carcinogenesis
TLDR
The variations in vitamin C transporter genes may regulate the active transport of vitamin C, and therefore have an impact on cancer risk, but further studies are needed to thoroughly elucidate their involvement in cancer biology. Expand
Role of p53 in transcriptional repression of SVCT2.
TLDR
The data suggests that p53 is a potent transcriptional repressor of SVCT2, a critical transporter of diet-derived ascorbic acid, across the plasma membranes of numerous essential tissue cell types. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 71 REFERENCES
Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells.
TLDR
It is shown that enterocytes from heterozygous SVCT2-knockout mice had lower sodium-dependent vitamin C accumulation compared to those from the wildtype, indicating that SV CT2 appears to be functional in enterocytes. Expand
Vitamin C transport systems of mammalian cells
TLDR
Two isoforms of vitamin C transport proteins, SVCT1 and SVCT2, have recently been cloned from humans and rats and are predicted to have 12 transmembrane domains, but they share no structural homology with other Na+ co-transporters. Expand
Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line
TLDR
Results suggest that high-dose supplements might not be the most efficient way of increasing the body pool of vitamin C. Expand
Human vitamin C (L-ascorbic acid) transporter SVCT1.
TLDR
The molecular cloning of a novel human cDNA encoding a vitamin C transporter SVCT1 is described and it is demonstrated that the human SLC23A1 gene product is a related high-affinity l-ascorbic acid transporter (SVCT2) that is widely distributed in brain, retina, and a host of endocrine and neuroendocrine tissues. Expand
Sodium-dependent ascorbic acid transporter family SLC23
TLDR
An SVCT1-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear. Expand
Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.
TLDR
The cloning and functional characterization of human SVCT2, a sodium-dependent vitamin C (ascorbate) transporter, is reported on, which exhibits 95% identity to its rat homolog. Expand
Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2).
TLDR
The complete sequencing and gene structure of SLC23A2, the gene encoding SVCT1, will serve as the foundation for investigation of the regulation and expression of the tissue-specific sodium-dependent vitamin C transporter, SLC 23A2. Expand
Translational control of the ascorbic acid transporter SVCT2 in human platelets.
TLDR
It is shown that platelets could compensate for fluctuations in ascorbate levels by modulating the expression of the Na+-dependent transporter SVCT2, and it was shown that changes in intracellular asCorbic acid content had physiological relevance, since they modulate the surface sulfhydryl content and the thrombus viscoelastic properties. Expand
A Human Sodium-Dependent Vitamin C Transporter 2 Isoform Acts as a Dominant-Negative Inhibitor of Ascorbic Acid Transport
TLDR
A mechanism of AA uptake regulation whereby an alternative SVCT2 gene product inhibits transport through the two known AA transporters is suggested. Expand
Immunohistochemical study on the distribution of sodium‐dependent vitamin C transporters in the respiratory system of adult rat
TLDR
These results provide the first evidence that intense SVCT1 and 2 IRs were found in the apical portion of the respiratory epithelial cells, suggesting that SVCT proteins in theapical portion could transport the reduced form of VC included in the airway surface liquid into the respiratory endothelial cells. Expand
...
1
2
3
4
5
...