SV40 virus transformation down-regulates endothelin receptor.

  title={SV40 virus transformation down-regulates endothelin receptor.},
  author={W. Chiou and J. Wang and C. Berg and J. R. Wu-wong},
  journal={Biochimica et biophysica acta},
  volume={1450 1},
Simian virus 40 (SV40) is an oncogenic DNA virus that induces malignant transformation. Endothelin (ET), a 21 amino acid peptide with mitogenic and anti-apoptotic effects, binds to G-protein coupled ETA and ETB receptors. This report examines the effect of SV40 transformation on the expression of ET receptors. Results from receptor binding and reverse transcription (RT)-polymerase chain reaction (PCR) studies show that human lung fibroblasts IMR90 and WI38 express both ETA and ETB receptors… Expand
5 Citations
The Roles of Endothelins in Proliferation, Apoptosis, and Angiogenesis
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Developmental Expression of Endothelin Receptors in Postnatal Swine Mesenteric Artery
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Endothelin and Its Inhibitors
Endothelin Ligands and Their Experimental Effects Within the Human Circulation and the Roles of Endothelins in Proliferation, Apoptosis and Angiogenesis are explained. Expand
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Characterization of a new endothelin receptor ligand by in vitro assays.


Cloning and expression of a cDNA encoding an endothelin receptor
The cloning of a complementary DNA encoding a bovine endothelin receptor is reported, which has a transmembrane topology similar to that of other G protein-coupled receptors and shows specific binding, with the highest selectivity to ET-1 in animal cells trans-fected with the cloned cDNA. Expand
Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth.
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Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer.
The potent vasoconstrictor endothelin-1 (ET-1) is at its highest concentration in the normal human ejaculate and is associated with the progression of metastatic prostate cancer and ETA expression are retained, whereas ETB receptor expression is reduced in human prostate cancer progression to metastases. Expand
Growth regulatory properties of endothelins
Evidence now suggests that the three isoforms of endothelins (ET-1 and the other two related isopeptides, ET-2 and ET-3) regulate growth in several of these cells, suggesting an important role mediating vascular remodeling in some cardiovascular diseases. Expand
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
The cloning of a complementary DNA encoding one subtype belonging to the superf amily of G protein-coupled receptors is reported, indicating that this cDNA encodes a 'nonselective' subtype of the receptor which is different from the vascular smooth muscle receptor. Expand
Endothelin attenuates apoptosis in human smooth muscle cells.
Endothelin (ET)-1, a 21-amino-acid peptide with mitogenic and vasoconstricting activities, not only acts as a mitogen, but also attenuates paclitaxel-induced apoptosis in smooth muscle cells, suggesting that ET is a potential survival factor for Smooth muscle cells. Expand
Signal transduction mechanisms mediating the vascular actions of endothelin.
This review describes how distinct pharmacological agents have been used to identify the diverse signaling mechanisms utilized by the ET isopeptides and how these actions are mediated via an interaction with two major subtypes of cell surface seven-transmembrane receptors. Expand
Endothelin is a potent mitogen for rat vascular smooth muscle cells.
Data indicate that ET is a potent mitogen as well as a constrictor for VSMC, suggesting its potential role in the development of vascular disease. Expand
Production and secretion of endothelin by hepatocellular carcinoma.
It is concluded that ET is produced by and released from a substantial number of HCC, which may stimulate proliferation of carcinoma cells as an autocrine or paracrine growth factor. Expand
Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate
It is shown that plasma immunoreactive endothelin concentrations are significantly elevated in men with metastatic prostate cancer and that every human prostate cancer cell line tested producesendothelin–1 messenger RNA and secretes immunore active endotheli. Expand