SV40 large T-antigen and human pleural mesothelioma

  title={SV40 large T-antigen and human pleural mesothelioma},
  author={Karl Dhaene and A. Verhulst and Eric A. E. Van Marck},
  journal={Virchows Archiv},
DNA-like sequences of the p53 and pRB-inactivating simian virus 40 large T-antigen (SV40 LTag) have recently been found in mesotheliomas in the United States and several European countries. Nuclear expression of SV40 LTag, possibly in concert with detectable telomerase activity, could be responsible for immortalisation of (pre)malignant clones, as suggested by the mesothelioma-specific latency period. Depending on the antibody used, different results have been observed regarding the subcellular… CONTINUE READING


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