SV40 infection induces telomerase activity in human mesothelial cells

@article{Foddis2002SV40II,
  title={SV40 infection induces telomerase activity in human mesothelial cells},
  author={Rudy Foddis and Assunta De Rienzo and Dominique Broccoli and Maurizio Bocchetta and Elizabeth Stekala and Paola Rizzo and Alessandra Tosolini and Jennifer V Grobelny and Suresh C. Jhanwar and Harvey I. Pass and Joseph R Testa and Michele Carbone},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={1434-1442}
}
Mesotheliomas are malignant tumors of the pleural and peritoneal membranes which are often associated with asbestos exposure and with Simian virus 40 (SV40) infection. Telomerase activity is repressed in somatic cells and tissues but is activated in immortal and malignant cells. We evaluated telomerase activity in seven primary malignant mesothelioma biopsies and matched lung specimens and 20 mesothelioma cell lines and eight corresponding primary tumor cultures. All the tumor biopsies, and… CONTINUE READING
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