SV40 and human cancer: A review of recent data

@article{Shah2007SV40AH,
  title={SV40 and human cancer: A review of recent data},
  author={K. Shah},
  journal={International Journal of Cancer},
  year={2007},
  volume={120}
}
  • K. Shah
  • Published 2007
  • Medicine
  • International Journal of Cancer
An unknown proportion of formalin‐inactivated poliovirus vaccine lots administered to millions of US residents between 1955 and 1963 was contaminated with small amounts of infectious simian virus 40 (SV40), a polyomavirus of the rhesus macaque. It has been reported that mesothelioma, brain tumors, osteosarcoma and non‐Hodgkin lymphoma (NHL) contain SV40 DNA sequences and that SV40 infection introduced into humans by the vaccine probably contributed to the development of these cancers. The… Expand
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TLDR
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TLDR
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TLDR
The capacity of the virus to infect humans and to cause disease, particularly in the lung and its serosal membrane, the pleura, is reviewed. Expand
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TLDR
The authors found no evidence of SV40 presence in tissue samples from 103 Slovenian patients with malignant pleural mesothelioma, and established an effective laboratory procedure for Simian virus 40 detection. Expand
No Implication of Simian virus 40 in pathogenesis of Malignant Pleural Mesothelioma in Slovenia
Background and aim Malignant mesothelioma is predominantly caused by asbestos exposure, although the association of Simian virus 40 in its pathogenesis is currently still under debate. Simian virusExpand
Epidemiology of Simian Polyomavirus SV40 in Different Areas of Russian Federation (RF)
DNA-containing polyomavirus SV40 was isolated in 1961 from poliovaccine prepared on kidney cell culture of M.mulatta naturally infected with this virus. Main part of poliovaccines (IPV and OPV) wasExpand
Detection of SV40 Large T Antigen in Malignant Lymphomas
TLDR
SV40 does not appear to be related to the pathogenesis of malignant lymphomas among Koreans, and from 158 non-Hodgkin’s lymphomas, none of the cases were positive for SV40 TAg. Expand
Variable frequency of polyomavirus SV40 and herpesvirus EBV in lymphomas from two different urban population groups in Houston, TX.
  • S. Toracchio, C. Kozinetz, +5 authors J. Butel
  • Biology, Medicine
  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2009
TLDR
It is demonstrated that, in a direct comparison, the prevalence of SV40 DNA in lymphomas can differ significantly between groups with different demographic distributions. Expand
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  • K. Shah
  • Biology, Medicine
  • Reviews in medical virology
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TLDR
It is premature to discuss or speculate on the potential role of SV40 in the development of human cancer until the presence of SV 40 in cancers and in human communities is established unequivocally, the risk factors for SV40 infection are elucidated, and the effect of SV30 exposure on the developmentof specific cancers is examined in the context of other known risk factors. Expand
Simian Virus 40 (SV40) and Human Cancers
TLDR
The evidence for and against recent assertions that SV40 is a human tumor virus are summarized. Expand
Absence of simian virus 40 (SV40) DNA in lymphoma samples from Tasmania, Australia
TLDR
The results demonstrate absence of SV40 in the lymphoid tissues of the study population in Tasmania, Australia, and suggest that SV40 does not explain the increasing incidence of NHL in this population. Expand
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TLDR
There may be an increased incidence of certain cancers among the 98 million persons exposed to contaminated polio vaccine in the U.S.; further investigations are clearly justified. Expand
Does Simian Virus 40 Cause Non-Hodgkin Lymphoma? A Review of the Laboratory and Epidemiological Evidence
TLDR
Many of the considerations raised in this review apply to the evaluation of data regarding other cancers, such as mesothelioma, brain tumors, and various sarcomas, for which an etiologic link with SV40 also has been proposed. Expand
Reappraisal of the strong association between simian virus 40 and human malignant mesothelioma of the pleura (Belgium)
TLDR
These results provide strong evidence for a lack of association of SV40 with most pleural mesotheliomas in the Belgian population and clearly demonstrate that an otherwise specific probe against SV40 could easily hybridize in quite a non-specific manner under recommended conditions. Expand
Simian virus 40 (SV40) and human cancer: a review of the serological data
TLDR
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TLDR
Screening human sera for antibodies to SV40 using direct and competitive enzyme-linked immunosorbent assays indicate that some individuals have BKV and/or JCV antibodies that cross-react with SV40, but they do not provide support for SV40 being a prevalent human pathogen. Expand
Polio vaccines, Simian Virus 40, and human cancer: the epidemiologic evidence for a causal association
TLDR
A meta-analysis of five published studies did not support the hypothesis that SV40 exposure increases the overall risk of cancer incidence or cancer mortality, and a new generation of molecular epidemiologic studies is necessary to properly address these issues. Expand
Presence of simian virus 40 (SV40) is not frequent in Swedish malignant mesotheliomas.
TLDR
The presence of SV40 is not frequent in Swedish MM patients, and could be confirmed by sequencing in only 3 of the 30 MM samples containing DNA that could be amplified by PCR. Expand
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