SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells.

@article{Vougiouklakis2015SUV420H1ET,
  title={SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells.},
  author={Theodore Vougiouklakis and Kenbun Sone and Vassiliki Saloura and Hyun-Soo Cho and Takehiro Suzuki and Naoshi Dohmae and Houda Alachkar and Yusuke Nakamura and Ryuji Hamamoto},
  journal={Oncotarget},
  year={2015},
  volume={6 41},
  pages={
          43162-71
        }
}
The oncogenic protein ERK, a member of the extracellular signal-regulated kinase (ERK) cascade, is a well characterized signaling molecule involved in tumorigenesis. The ERK signaling pathway is activated in a large proportion of cancers and plays a critical role in tumor development. Functional regulation by phosphorylation of kinases in the ERK pathway has been extensively studied, however methylation of the ERK protein has not been reported to date. Here, we demonstrated that the protein… CONTINUE READING

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